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Signal transduction ________________________________________________



Suman Banik , Indrani Bose


Suman Banik

One of the important functions of living organism is to respond to the changes made in the environment as a outcome of which one or more signal transduction pathways get activated and/or repressed resulting into several downstream gene expression and/or repression. In bacterial kingdom signal transduction typically takes place through two-component system (TCS) comprised of sensor kinases and response regulators. Using both mathematical and computational approaches we plan to model the response of Bordetella pertussis, Mycobacterium tuberculosis and Vibrio harveyi to the environmental change(s) and downstream gene expression/repression mediated by TCS. The ultimate goal of our study is to generate the qualitative features of in vivo and/or in vitro experiments from the model and to make new testable predictions.


Indrani Bose and Subhasis Banerjee

      Dynamics of Jasmonate (JA) Signaling Pathway:

Have developed a theoretical model incorporating  molecular detail based on recent experimental evidence

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 Model demonstrates formation of transient JA pulse, makes a number of testable predictions.



 Indrani Bose and Bhaswar Ghosh

      Modeling Cell Division Cycle:

Signaling pathway involving key components is modeled to show that cell division cycle is not arrested on DNA damage when there is a loss in copy number of  p53 gene from two to one due to mutation (recent experimental evidence: loss of only one gene copy sufficient to trigger cancer)

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DNA damage network resulting in cell cycle arrest. The cycle is not arrested
when p53 gene copy number is reduced from two to one.

Further details: Gene copy number and cell cycle arrest by Ghosh B. and Bose I. , Physical Biology 3, 29 (2006)


p53-MDM2 network: from oscillations to apoptosis:

      

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Pulses of p53 protein produced on DNA damage

 

Our model makes key predictions on specific aspects of cell cycle arrest and cell death with relevance for nutlin-based cancer therapy.

 

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(a) p53-mediated apoptotic pathway, (b) subnetwork of regulatory interactions involving p53, MDM2 and p21


Further details: The p53-MDM2 network: from oscillations to apoptosis by Bose I. and Ghosh B., J. Biosci., 32, 991 (2007)



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