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Regulation of Gene Expression ________________________________________________

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Joyoti Basu, Indrani Bose, Manikuntala Kundu

Regulation of Gene Expression in Mycobacterium tuberculosis (Mtb) and plant signaling

Have combined theoretical modeling with single cell experiments to probe regulation of gene expression in stringent response pathway of M. smegmatis subjected to nutrient depletion
Have investigated dynamics of autoactivated two-component system mprA-mprB
Switch to mycobacterial persistence under nutrient depletion identified (See also Phenotypic Heterogeneity )

Indrani Bose and Subhasis Banerjee:

Functional characteristics of double positive feedback loop coupled with Autorepression:

Two-gene motif

A two-gene motif involving positive feedback loop coupled with autorepression forms core of transcriptional regulatory network controlling pancreatic beta cell function
Maturity-onset-diabetes of the young (MODY) originates from loss of a gene copy due to mutation
Have proposed a model based on two-gene motif to provide insight on possible origins of MODY and functional utility of two-gene motif

Further details: Functional characteristics of a double positive feedback loop coupled with autorepression by Banerjee S. and Bose I., Physical Biology 5 046008 (2008)

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