Bioinformatics Centre
A.J.C. Bose Centenary Building,
P-1/12, CIT Scheme - VII M,
Kolkata - 700 054, India




Centre for Excellence in Bionformatics


Tel:+91-33-2355 6626 / 2359 3274

Fax:+91-33-2355 3886

[BIC Profile]



Area of Research: Evolutionary bioinformatics

Different proteins evolve at different rates. Elucidation of the determinants of the rate of protein sequence evolution is one of the great challenges in evolutionary biology. The main theme of our research goal is to identify and understand the different evolutionary forces by analyzing the genomic and functional data of various organisms.

Key Publications:

Podder S, Ghosh TC. Exploring the Differences in Evolutionary Rates between Monogenic and Polygenic Disease Genes in Human. Molecular Biology and Evolution 2010;27(4):934-941. PubMed ID: 19955474.

Begum T, Ghosh TC. Understanding the Effect of Secondary Structures and Aggregation on Human Protein Folding Class Evolution. Journal of Molecular Evolution 2010;71(1):60-69. PubMed ID: 20614111.


Chakraborty S, Ghosh TC. Protein complex forming ability is favored over the features of interacting partners in determining the evolutionary rates of proteins in the yeast protein-protein interaction networks. BMC Syst Biol 2010;4(155). PubMed ID: 21073713.


Manna B, Bhattacharya T, Kahali B, Ghosh TC. Evolutionary constraints on hub and non-hub proteins in human protein interaction network: Insight from protein connectivity and intrinsic disorder. Gene 2009;434(1-2):50-55. PubMed ID: 19185053.


Basak S, Roy S, Ghosh TC. On the origin of synonymous codon usage divergence between thermophilic and mesophilic prokaryotes. Febs Letters 2007;581(30):5825-5830. PubMed ID: 18047839.

Mukhopadhyay P, Basak S, Ghosh TC. Nature of selective constraints on synonymous codon usage of rice differs in GC-poor and GC-rich genes. Gene 2007;400:71-81. PubMed ID: 17629420.

D'Onofrio G, Ghosh TC. The compositional transition of vertebrate genomes: an analysis of the secondary structure of the proteins encoded by human genes. Gene 2005;345(1):27-33. PubMed ID: 15716110.


Gupta SK, Majumdar S, Bhattacharya TK, Ghosh TC. Studies on the relationships between the synonymous codon usage and protein secondary structural units. Biochemical and Biophysical Research Communications 2000;269(3):692-696. PubMed ID: 10720478.

© Bioinformatics Centre (BIC), Bose Institute, Kolkata 2011, Last updated on: January 30, 2011