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bose

Bioinformatics Centre
A.J.C. Bose Centenary Building,
P-1/12, CIT Scheme - VII M,
Kolkata - 700 054, India



Dr. SHUBHRA GHOSH DASTIDAR




RESEARCH I LAB MEMBERS PUBLICATIONS

Assistant Professor

Center of Excellence in Bionformatics

sgd(AT)jcbose.ac.in

Tel:+91-33-2569 3332

Fax:+91-33-2355 3886

[BIC Profile]

 

 

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Area of Research: Structural dynamics of biomolecules

The atoms and molecules in a cell are always jiggling, dancing and bumping into each other and occasionally carrying out a specific reaction or a process. This forms the lifeline of all organisms. Hence it is important to understand how exactly this is choreographed. The most sophisticated experimental technology is only just beginning to give us a glimpse of this intricate dance but at a very coarse level. Computer simulations of this dance are increasingly providing much needed atomistic details. The general interest of our group is to gain novel insight into biology from the computer simulations of such events. Such methods can be used to both understand the dances and what happens when things go wrong that lead to a disease such as cancer. Using those information one can start designing drugs in a rational manner. Right now the p53-pathway and Bcl2 family are two primary areas of focus, where both are promising areas of cancer therapeutics. We work in a truly interdisciplinary manner and so students/postdocs coming from various disciplines e.g. Chemistry, Physics, Biology, Computer Science etc. can contribute to our laboratory with their own domain of expertise and can expand knowledge in other areas.

Ph.D. position available: MSc in Chemistry/Biochemistry/Biophysics and CSIR/UGC NET qualified candidates can send CV by email.

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Key Publications:

Maity A, Majumdar S, Priya P, De P, Saha S, Dastidar SG, Adaptability in protein structures: Structural dynamics and implications in ligand design (Review), J Bio Mol Struc Dyn (2014) (In Press).

Maity A, Yadav S, Verma CS, Dastidar SG, Dynamics of Bcl-xl in Water and Membrane: Molecular Simulations PLoS One (2013) 8, e76837.

Sengupta A, Sarkar A, Priya P, Dastidar SG, Das S, New Insight to Structure-Function Relationship of GalNAc Mediated Primary Interaction between Insecticidal Cry1Ac Toxin and HaALP Receptor of Helicoverpa armigeraí. PLoS One (2013) 8, e78249.

Chakraborti S, Chakravarty D, Gupta S, Chatterji BP, Dhar G, Poddar A, Panda D, Chakrabarti P, Dastidar SG(*) and Bhattacharyya B (*),Discrimination of Ligands with Different Flexibilities Resulting from the Plasticity of the Binding Site in Tubulin, Biochemistry (2012) 51, 7138-48.

Dastidar SG, Lane DP, Verma CS. Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding, Cell Cycle (2012); 11: 2239-47.

Brown CJ, Dastidar SG , S. T. Quah, A. Lim, B. Chia, C. S. Verma. C-Terminal Substitution of MDM2 Interacting Peptides Modulates Binding Affinity by Distinctive Mechanisms PLoS One (2011); 6, e24122

Fuentes G, Dastidar SG, Madhumalar A, Verma CS. Role of protein flexibility in the Discovery of New Drugs (Review Article), Drug Dev Res (2011), 71, 26

Dastidar SG (*), Raghunathan D, Nicholson J, Hupp TR, Lane DP, Verma CS (*). Chemical States of the N-terminal “lid” of MDM2 regulate p53 binding. Cell Cycle (2011); 10: 82-89.

Dastidar SG, Madhumalar A, Fuentes G, Lane DP, Verma CS. Forces mediating protein-protein interactions: a computational study of p53 "approaching" MDM2. Theor Chem Acc (2010); 125: 621.

Brown CJ, Dastidar SG, See H, Comber DW, Ortiz-Lombardía M, Verma CS, Lane DP. Rational Design and biophysical characterization of Thioredoxin-based aptamers: Insights into peptide grafting. J Mol Biol (2010); 235: 871.
 

Dastidar SG, Lane DP and Verma CS. Multiple conformation give rise to similar binding affinities: Molecular simulation of p53-MDM2. J Am Chem Soc (2008); 130: 13514
(showcased in “JACS-Select”)

 




© Bioinformatics Centre (BIC), Bose Institute, Kolkata 2011, Last updated on: September 27, 2013