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Bioinformatics Centre
A.J.C. Bose Centenary Building,
P-1/12, CIT Scheme - VII M,
Kolkata - 700 054, India



Dr. ZHUMUR GHOSH


Position of JRF in a ICMR project will be advertised soon. NET/GATE is essential. Individuals can enquire in advance at ghosh.jhumur@gmail.com.

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RESEARCH I LAB MEMBERS I PUBLICATIONS

 

zhumur@jcbose.ac.in

ghosh.jhumur@gmail.com

Tel:

Fax:+91-33-2355 3886

    [BIC Profile]

 

Area of Research: Stem Cells, microRNA and Gene Expression, Microarray, ESCs, iPSCs and Regenerative medicine, Cancer Stem cells, Computational Genomics, Epigenetics and reprogramming of induced pluripotent stem cells, microRNAs in disease networks & systems biology

A fundamental question in stem cell biology is what determines the self-renewal and pluripotency of stem cells? Recent data indicate that RNAi may play an important role in these processes. We aim to understand the role of small regulatory RNAs specially microRNA in the self-renewal and pluripotency of embryonic stem cells(ES cells) and induced pluripotent stem cells (iPS cells). We plan to analyze the miRNA and mRNA microarray data of both ES and iPS cells systematically and investigate the function of individual miRNAs in these and identify their target genes. Moreover, we have identified particular miRNAs that are likely candidate genes for several human diseases like SARS, ischemic heart disease.

Apart from ES and iPS cells, recently we are interested to gear our research towards a small subpopulation of cells identified in cancers that have stem cell properties. These cells hopefully will come up with appropriate answers to the following questions: Why are most cancers difficult to eradicate and easy to recur and metastasize? Why are some tumors resistant to therapy? Why are some tumors highly aggressive? Are we targeting the right cells? Cancer stem cells (CSCs) are thus the cells within a tumor that possess the capacity to self-renew and produce heterogeneous lineages of cancer cells that comprise the tumor. The self-renewing CSC is characterized by continuous expansion of cells in cancer resulting in the development of a tumor, unlike normal stem cells in which the total number of stem cells in a tissue is highly regulated and expansion beyond the normal level is restricted by genetic programs. MicroRNAs have recently been shown to be acting as micro-switches that reveal certain hidden dimensions of CSC cycle control. We aim towards elucidating miRNA-mediated regulatory networks in CSCs.
 

Key Publications:

Hu S, Wilson KD, Ghosh Z, Han L, Wang Y, Lan F, Ransohoff KJ, Wu JC (2012) MicroRNA-302 increases reprogramming efficiency via repression of NR2F2. Stem Cells. 2012. Pubmed ID: 23136034.

Kumar R, Halder P, Sahu SK, Kumar M, Kumari M, Jana K, Ghosh Z, Sharma P, Kundu M, Basu J (2012) Identification of a novel role of ESAT-6-dependent miR-155 induction during infection of macrophages with Mycobacterium tuberculosis. Cell Microbiol. 2012 14(10):1620-1631. PubMed ID: 22712528.

Reddy S, Zhao M, Hu DQ, Fajardo G, Hu S, Ghosh Z, Rajagopalan V, Wu JC, Bernstein D (2012) Dynamic microRNA expression during the transition from right ventricular hypertrophy to failure. Physiol Genomics. 44(10):562-575. PubMed ID: 22454450.
 

Ghosh Z, Huang M, Hu S, Wilson KD, Dey D, Wu JC (2011) Dissecting the oncogenic and tumorigenic potential of differentiated Human induced pluripotent stem cells and human embryonic stem cells. Cancer Research, 71(14): 5030–5039. PubMed ID: 21646469.

Pearl JI, Leveson-Gower DB, Lee A, Sun N, Ghosh Z, Negrin RS, Davis MM, Wu JC (2011) Inducing immunotolerance to pluripotent stem cells for long-term engraftment. Cell Stem Cell, 8(3):309-317. PubMed ID: 21362570. [Highlighted in ScienceDaily]

Hu S, Huang M, Li Z, Jia F, Ghosh Z, Lijkwan MA, Fasanaro P, Sun N, Wang X, Martelli F, Robbins RC, Wu JC (2010) MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. Circulation, 122 (11 Suppl):S124-31. PubMed ID: 20837903.

Ghosh Z, Wilson KD, Wu Y, Hu S, Quertermous T, Wu JC (2010) Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. PLoS One, 5(2):e8975. PubMed ID: 20126639.

Wilson KD, Hu S, Venkatasubrahmanyam S, Fu JD, Sun N, Abilez OJ, Baugh JJ, Jia F, Ghosh Z, Li RA, Butte AJ, Wu JC (2010) Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR-499. Circ Cardiovasc Genet., 3(5):426-35. PubMed ID: 20733065.

Ghosh Z, Mallick B, Chakrabarti J (2009) MicroRNome analysis unravels the molecular basis of SARS infection in bronchoalveolar stem cells. PLoS One, 4(11):e7837. PubMed ID: 19915717.

Ghosh Z, Mallick B, Chakrabarti J. Cellular versus viral microRNAs in host-virus interaction (2010) Nucleic Acids Res., 37(4):1035-48. PubMed ID: 19095692.

Köhrer C, Srinivasan G, Mandal D, Mallick B, Ghosh Z, Chakrabarti J, Rajbhandary UL (2008) Identification and characterization of a tRNA decoding the rare AUA codon in Haloarcula marismortui. RNA, 14(1):117-26. PubMed ID: 17998287. (featured on journal cover)
 

 




© Bioinformatics Centre (BIC), Bose Institute, Kolkata 2011, Last updated on: Nov 24, 2012