Bioinformatics Centre
A.J.C. Bose Centenary Building,
P-1/12, CIT Scheme - VII M,
Kolkata - 700 054, India


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Tel: +91-33-2569 3329

Fax:+91-33-2355 3886



Area of Research: Regulatory RNAs, Stem cells, Bioinformatics & Systems biology

A fundamental question in stem cell biology is what determines the self-renewal and pluripotency of stem cells? What are the substates of pluripotency? How do these states differ from each other?

Naive and primed pluripotent states are very similar but they do differ from each other in terms of their degree of pluripotency. We are looking into the specific signatures which make them different.

On the other hand we have geared our research towards identifying and characterizing a small subpopulation of cells in cancers that have stem cell properties. Cancer stem cells (CSCs) are thus the cells within a tumor that possess the capacity to self-renew and produce heterogeneous lineages of cancer cells that comprise the tumor. The self-renewing CSC is characterized by continuous expansion of cells in cancer resulting in the development of a tumor, unlike normal stem cells in which the total number of stem cells in a tissue is highly regulated and expansion beyond the normal level is restricted by genetic programs. Regulatory RNAs have recently been shown to be acting as switches that reveal certain hidden dimensions of CSC biology. We are mainly interested in microRNAs, piwi interacting RNAs and long noncoding RNAs. We aim towards elucidating these regulatory networks in CSCs.

© Bioinformatics Centre (BIC), Bose Institute, Kolkata 2011, Last updated on: June 27, 2016