Bioinformatics is a newly emerging interdisciplinary research area which may be defined as an interface between biological and computational sciences. The word “bioinformatics” is derived by combining biology and informatics. It has its roots in computational biology, a field that has been driven during the last two decades largely by enormous amounts of nucleotide sequence data generated and deposited in the public databases. It is a science of storing, extracting, organizing, analyzing, interpreting and utilizing information for holistic research in biology and biotechnological product development. India was one of the first developing countries that had taken a giant step in 1987 and established a Biotechnology Information System Network (BTISnet) under the Department of Biotechnology (DBT). The Bioinformatics Centre of Bose institute was established in 1988 as one of the ten nodal centres under this programme for providing infrastructure support for training manpower in this emerging area. In 2004 it was recognized as a “Centre of Excellence” in Bioinformatics. It offers research programs in various branches of bioinformatics such as Molecular Modeling, Drug Design, Molecular Evolution, Bioinformatics of Stem Cells and microRNA, Systems Biology etc.